|Coal Worker's||Carbon dust|
Most coal miners!
|Massive exposure so diffuse fibrosis|
= Black Lung
This + RhA = Caplan syndrome
|Mild exposure to C just causes anthracosis - lots of "dust cells" - macrophage filled with C|
No clinically significant
All of us! Pollution!
Lungs fibrosed and "shrunk"
Silica miners, sandblasters
|Fibrotic nodules in upper lung lobes ||Inc TB risk! only one that does so|
Silica impairs macrophage phagolysosome formation
|Berrylliosis||Berryllium - miners, aerospace engineers||Non-caseating granulomas in lung, hilar lymph nodes + organs|
(sounds a lot like sarcoidosis! careful!)
|Inc lung Ca risk|
builders, plumbers, shipyard workers
Small blue fibres worse
|Lung and plura (plaques) fibrosis|
Inc risk of
|Lesions may have long, gold-brown fibres stuck to iron proteins = Ferruginous (Absestos) Bodies|
This is confirmatory for exposure
Causes fibrosis of lung + plura
& Ca of lung + plura [latter rarer]